Parkinson'S Essay Conclusion

Parkinson'S Essay Conclusion-44
Caffeine is an antagonist at adenosine 2A receptors (A2A-R) located exclusively in the striatum, and specifically in medium spiny neurons coexpressing D2 dopamine receptors, a critical link in the indirect motor pathway.A plausible model can be proposed by which blockade of adenosine receptors would protect dopaminergic neurons in the substantia nigra from excitotoxic injury.

Caffeine is an antagonist at adenosine 2A receptors (A2A-R) located exclusively in the striatum, and specifically in medium spiny neurons coexpressing D2 dopamine receptors, a critical link in the indirect motor pathway.A plausible model can be proposed by which blockade of adenosine receptors would protect dopaminergic neurons in the substantia nigra from excitotoxic injury.

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This combination therapy has allowed many patients to live reasonably normal lives.

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Other findings in people affected by Parkinson disease include mitochondrial dysfunction, leading to increased production of free radicals that cause significant damage to brain cells, and heightened sensitivity of the immune system and neurons to molecules called cytokines, which stimulate inflammation.-dopa).

Levodopa crosses the blood-brain barrier (a physiological partition blocking the entry of large molecules into the central nervous system) via special transport proteins and is converted to dopamine in the brain, primarily in the region containing the substantia nigra.

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